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   2004 NEWS ARCHIVE
 
METABOLEX RAISES $44 MILLION IN ADDITIONAL PRIVATE FINANCING
Edward E. Penhoet, Ph.D., Chiron Co-Founder, Elected Chairman of the Board
November 30, 2004
Metabolex, Inc., a privately held pharmaceutical firm that discovers and develops drugs to treat diabetes and related metabolic diseases, today announced that it has raised $44 million in a private equity financing led by Alta Partners. Additional new investors in the round include Venrock Associates, Versant Ventures and Novo A/S. Previous Metabolex investors participating in this closing included Bay City Capital, KBC Bank & Insurance Group, and Birchmere Ventures, along with VantagePoint Venture Partners. This financing is the third close of the company’s financing announced in August 2003, bringing the total amount raised in this round to $75 million...
 
METABOLEX ANNOUNCES START OF PHASE 2 TRIAL OF ITS NOVEL INSULIN SENSITIZER,
Metaglidasen
Drug Well-tolerated in Phase 1 Study; G.I. Toxicity of Halofenate Not Seen
March 2, 2004

Metabolex, Inc., today announced the start of its Phase 2 study of its investigational insulin sensitizer, metaglidasen. The double-blind, placebo-controlled study will enroll approximately 200 patients with type 2 diabetes who are currently on insulin, but whose fasting blood-glucose levels are not well controlled. Researchers at 29 centers throughout the United States and Mexico will participate in the study, which is expected to complete in early 2005....

 
METABOLEX APPOINTS DAVID B. KARPF, M.D. AS CHIEF MEDICAL OFFICER
February 9, 2004
Metabolex, Inc., a privately held pharmaceutical firm that discovers and develops drugs to treat diabetes and related metabolic diseases, today announced the appointment of David B. Karpf, M.D. as chief medical officer, effective January 30, 2004. Dr. Karpf joins Metabolex from Geron Corporation, where he served as executive medical director, clinical and regulatory affairs since 2001....
 
METABOLEX ANNOUNCES EXTENSION OF DRUG DISCOVERY COLLABORATION WITH PFIZER FOCUSED ON INSULIN SECRETION DEFECTS IN DIABETES
January 21, 2004
Metabolex, Inc., a privately held pharmaceutical firm that discovers and develops drugs to treat diabetes and related metabolic diseases, today announced a one-year extension of its research collaboration with Pfizer Inc. This collaboration, first initiated with Parke-Davis (since acquired by Pfizer) in December 1998, is aimed at discovering new drugs that treat patients with type 2 diabetes by counteracting defects in insulin secretion...
 
METABOLEX RAISES $4 MILLION IN SECOND CLOSE OF PRIVATE FINANCING FOR TOTAL FUNDING OF $31 MILLION
January 12, 2004
Metabolex, Inc., a privately held pharmaceutical firm that discovers and develops drugs to treat diabetes and related metabolic diseases, today announced that it has raised an additional $4 million in a second close of its recent private equity financing. This close brings the total raised by Metabolex in this sixth round of funding to $31 million...